Title:Undressing the Fungal Cell Wall/Cell Membrane - the Antifungal Drug Targets
Volume: 19
Issue: 20
Author(s): Rui Tada, Jean-Paul Latge and Vishukumar Aimanianda
Affiliation:
Keywords:
Aspergillus fumigatus, Candida albicans, azole, echinocandin, cell wall, polysaccharide, chitin, glucan, mannan, antifungal
drugs.
Abstract: Being external, the fungal cell wall plays a crucial role in the fungal life. By covering the underneath cell, it offers mechanical
strength and acts as a barrier, thus protecting the fungus from the hostile environment. Chemically, this cell wall is composed of different
polysaccharides. Because of their specific composition, the fungal cell wall and its underlying plasma membrane are unique targets for
the development of drugs against pathogenic fungal species. The objective of this review is to consolidate the current knowledge on the
antifungal drugs targeting the cell wall and plasma membrane, mainly of Aspergillus and Candida species – the most prevalent fungal
pathogens, and also to present challenges and questions conditioning the development of new antifungal drugs targeting the cell wall.
