Title:Nitrogen Containing Privileged Structures and their Solid Phase Combinatorial Synthesis
Volume: 16
Issue: 5
Author(s): Amit Verma, Mange Ram Yadav, Rajani Giridhar, Navnit Prajapati, Avinash C. Tripathi and Shailendra K. Saraf
Affiliation:
Keywords:
Benzodiazepine, combinatorial synthesis, cyclic peptides, nitrogen heterocyclics, privileged structures, purines and
pyrimidines, solid-phase synthesis.
Abstract: The existence of preferred molecular scaffolds that possess inherent biological activity, called privileged
structures, is now well recognized. Such privileged structures not only provide enhanced drug-like properties but also give
new hits for developing leads. The synthesis of combinatorial libraries, especially with the insertion of privileged
substructures into heterocyclic moieties containing nitrogen, provides for a greater probability of the discovery of novel
lead compounds using chemical transformation. The review focuses on the progress in the solid-phase synthetic strategies
of nitrogen containing privileged structures over the years.
