Recent Progress in Molecular Mechanisms of Angiotensin II Type 1 and 2 Receptors

Shin-ichiro      Miura; Satoshi      Imaizumi; Keijiro      Saku

doi:10.2174/1381612811319170002

Abstract

The renin-angiotensin system hormone angiotensin II (Ang II) plays a central role in the pathophysiology of vasoconstriction, cardiovascular hypertrophy and hyperplasia. Two distinct subtypes of Ang II receptor, type 1 (AT₁) and type 2 (AT₂), have been identified, and both have been shown to belong to the G protein-coupled receptors (GPCRs) superfamily. AT₁ and AT₂ receptors may have antagonistic action. While the crystal structures of GPCRs obtained from the rhodopsin, opsin, and ß₁ and ß₂- adrenergic receptors have recently been described in different conformational states, the crystal structures of Ang II receptors have not been elucidated. The conformation range and dynamics of the effects of ligands on GPCRs may differ from one receptor to another. This review focuses on the structure and function of Ang II receptors, such as the movement of transmembrane helices, functional selectivity for AT₁ receptor activation, the possibility of constitutive activity of wild-type Ang II receptors and the homo- and hetero-dimerization of Ang II receptors.

Keywords: Angiotensin II receptors, G protein-coupled receptor, structure and function.

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