Study on Synthesis of 2-(Substituted Benzylidene)amino-2-Deoxy-1,3,4,6- Tetra-O-Acetyl-β-D-Glucopyranoses from D-Glucosamine

Title:Study on Synthesis of 2-(Substituted Benzylidene)amino-2-Deoxy-1,3,4,6- Tetra-O-Acetyl-β-D-Glucopyranoses from D-Glucosamine

Volume: 10 Issue: 2

Author(s): Nguyen Dinh Thanh and Nguyen Van Quoc

Affiliation:

Keywords: D-glucosamine, substituted benzaldehydes, schiff bases, tetra-O-acetyl-β-D-glucosamine hydrochloride, DPPH

Abstract: The conditions in catalysts and in reaction time for the reaction of protected α-D-glucosamine hydrochloride with different substituted benzaldehydes have been investigated in the presence of various inorganic and organic bases. Based on obtained results, the general procedure for the synthesis of Schiff’s bases from tetra-O-acetyl-β-D-glucosamine hydrochloride and substituted benzaldehydes has been optimized. Reaction yields were 28-80%. Azomethines 6a-i have the scavenging effect on the DPPH radical with values of IC₅₀ of 50-75 μM.

Cite this article as:

Dinh Thanh Nguyen and Van Quoc Nguyen, Study on Synthesis of 2-(Substituted Benzylidene)amino-2-Deoxy-1,3,4,6- Tetra-O-Acetyl-β-D-Glucopyranoses from D-Glucosamine, Letters in Organic Chemistry 2013; 10 (2) . https://dx.doi.org/10.2174/1570178611310020003