Title:TRP Channels in Vascular Disorders
Volume: 13
Issue: 3
Author(s): Alexander V. Zholos and Timothy M. Curtis
Affiliation:
Keywords:
Calcium signalling, endothelium, TRP channels, vascular disease, vascular smooth muscle
Abstract: In recent years, research on the roles of TRP channels in vascular function and disease has undergone a rapid
expansion from tens of reports published in the early 2000s to several hundreds of papers published to date. Multiple TRP
subtypes are expressed in vascular smooth muscle cells and endothelial cells, where they form diverse non-selective
cation channels permeable to Ca2+. These channels mediate Ca2+ entry following receptor stimulation, Ca2+ store depletion
and mechanical stimulation of vascular myocytes and endothelial cells. The complex molecular composition and signalling
pathways leading to the activation of various vascular TRP channels and the growing evidence for their involvement
in various vascular disorders, including dysregulation of vascular tone and hypertension, impaired endothelium-dependent
vasodilatation, increased endothelial permeability, occlusive vascular disease, vascular injury and oxidative stress, are
summarised and discussed in this review.
