Title:Genome-Wide Integrated Analyses of Androgen Receptor Signaling in Prostate Cancer Based on High-Throughput Technology
Volume: 14
Issue: 4
Author(s): Kuniko Horie-Inoue and Satoshi Inoue
Affiliation:
Keywords:
Androgen receptor, cap analysis gene expression, chromatin immunoprecipitation, prostate cancer
Abstract: The androgen receptor (AR) is a steroid hormone receptor that functions as a ligand-dependent transcriptional
factor, which plays a key role in the development and progression of prostate cancer. Recent advancement in highthroughput
technologies including microarrays and deep-sequencing provides unbiased genome-wide knowledge on the
AR signaling including datasets for androgen-regulated gene expression and genomic binding sites for AR. In the present
review, we will briefly summarize the main features of the AR signaling as well as the individual AR target genes identified
by the integration of multiple datasets in prostate cancer. Cap analysis gene expression (CAGE) is also featured as a
unique transcriptome method, which particularly determines the androgen-dependent transcription start points in prostate
cancer.
