Title:Radical Scavengers as Ribonucleotide Reductase Inhibitors
Volume: 12
Issue: 24
Author(s): Arijit Basu and Barij Nayan Sinha
Affiliation:
Keywords:
Di-iron/radical site, ligand based drug design, quantum mechanics/molecular mechanics, radical scavengers, ribonucleotide
reductase, structure based drug design
Abstract: This paper compiled all the previous reports on radical scavengers, an interesting class of ribonucleotide reductase
inhibitors. We have highlighted three key research areas: chemical classification of radical scavengers, structural and
functional aspects of the radical site, and progress in drug designing for radical scavengers. Under the chemical classification
section, we have recorded the discovery of hydroxyurea followed by discussions on hydroxamic acids, amidoximes,
hydroxyguanidines, and phenolic compounds. In the next section, we have compiled the structural information for the
radical site obtained from different crystallographic and theoretical studies. Finally, we have included the reported ligand
based and structure based drug-designing studies.
