Title:Antioxidant and Antiinflammatory Activities of Curcumin on Diabetes Mellitus and its Complications
Volume: 19
Issue: 11
Author(s): Bo Meng, Jun Li and Hong Cao
Affiliation:
Keywords:
Diabetes mellitus, curcumin, oxidative stress, inflammatory cytokines, mortality, phytochemical, turmeric, anti-oxidant, nosogenesis, inflammation
Abstract: Diabetes mellitus (DM) has reached pandemic status and shows no signs of abatement. It can severely impair people’s quality
of life and affects patients all over the world. Since it is a serious, chronic metabolic disease, it can bring about many kinds of complications,
which can in turn increase mortality. In recent decades, more and more studies have shown that oxidative stress and inflammatory
reactions play critical roles in the pathogenesis of DM. There is an increasing demand for natural antidiabetic medicines that do not have
the same side effects as modern drugs. Curcumin, a phytochemical found in the spice turmeric, has been used in India for centuries, and it
has no known side effects. It has been shown to have some beneficial effects against various chronic illnesses. Many of these therapeutic
actions can be attributed to its potent anti-oxidant and anti-inflammatory activities. In view of the oxidative stress and inflammatory
mechanisms of DM, curcumin can be considered suitable for the prevention and amelioration of diabetes. In this review, we summarize
the nosogenesis of DM, giving primary focus to oxidative stress and inflammation. We discuss the anti-oxidant and anti-inflammatory activities
of curcumin in DM and its ability to mitigate the effects on DM and its associated complications in detail.