Title:Xenobiotic Sulphation and its Variability During Inflammation: a Factor in Adverse Drug Reactions?
Volume: 14
Issue: 3
Author(s): R.H. Waring, R.M. Harris, J.O. Hunter and S.C. Mitchell
Affiliation:
Keywords:
Inflammation, Illness, Sulphation, Drug Metabolism, Xenobiotic, Drug Reactions, SULT, Isoforms, Phase 2, Cytokines, Sulphate
Abstract: The interactions between disease processes and the metabolism of therapeutic drugs have not been systematically investigated.
Inflammation, with the presence of pro-inflammatory cytokines, affects Phase 1 metabolism, particularly the activity of the CYP isoforms.
Inflammatory factors also alter the activity of some Phase 2 enzymes, particularly the sulphotransferases (SULT isoforms) responsible
for drug sulphonation and the enzyme pathway involved in the supply of sulphate for this reaction. Being ill may, therefore, in itself
make drug metabolism unpredictable.
