Title:Roles of miRNA in the Initiation and Development of Colorectal Carcinoma
Volume: 19
Issue: 7
Author(s): Yiming Ma, Weiwei Li and Hongying Wang
Affiliation:
Keywords:
miRNA, colorectal carcinoma, carcinogenesis, metastasis, small non-coding RNAs, post-transcriptional regulators, biomarkers, p53, NF-kappa B, cancer stem cell
Abstract: MicroRNAs (miRNAs) are small non-coding RNAs exhibiting critical functions as post-transcriptional regulators. Due to the
importance and extensive influence of miRNAs on genes, dysregulation of miRNAs has been associated with various types of cancer,
with more prominent being colorectal carcinoma (CRC). Increasing evidence suggests that miRNAs mediate the initiation and development
of CRC and also act as potential biomarkers for both diagnosis and prognosis. In this review, we summarize the recent advancement
of miRNA research in CRC, in particular, the miRNAs which interact with critical pathways such as p53, NF-kappa B, beta-catenin
pathways and also play a significant role in the regulation of EMT and maintenance of cancer stem cell.
