Title:Ascorbic Acid in Cancer Chemoprevention: Translational Perspectives and Efficacy
Volume: 13
Issue: 14
Author(s): Mohammad F. Ullah, Showket H. Bhat, Eram Hussain, Faisel Abu-Duhier, Aamir Ahmad and S. M. Hadi
Affiliation:
Keywords:
Ascorbic acid, chemoprevention, phytochemicals
Abstract: Chemoprevention, which is referred to as the use of nontoxic natural or synthetic chemicals to intervene in
multistage carcinogenesis has since decades attracted a considerable interest in plant-derived chemical constituents often
termed as “phytochemicals” or sometimes as “Nutraceuticals” in case they are derived from dietary sources. A comprehensive
search of the literature show that such an interest in natural product pharmacology has surged in the last 25 years
and particularly risen at exponential rates since the last one decade. Phytochemicals such as curcumin (from spice turmeric),
resveratrol (from red wine) and genistein (from soy) share the major efforts as indicated by overwhelming publications,
despite skepticism concerning their bioavailability. Ascorbic acid (AA), the popular anti-oxidant in fruits and vegetables,
has even a longer historical perspective than these dietary agents as for more than 35 years; there had been lingering
questions about the efficacy of AA in cancer therapy. The footprints of AA from “scurvy” to “cancer” though complex
seems to carry potential provided the puzzle could be set right. The use of AA in cancer treatment has been debated extensively
as evident from the literature but surprisingly the complementing early phase bench work on the mechanistic studies
for anticancer action was rather retarded. Proposed mechanisms of action for AA in the prevention and treatment of
cancer includes antioxidant as well as pro-oxidant properties, stimulation of the immune system, altering carcinogen metabolism,
enhancement of collagen synthesis necessary for tumor encapsulation and interference with cancer cell signaling.
The observation that the intravenous administration of AA enhances its bioavailability to the extent of deriving pharmacological
benefits against cancer has in recent years partially supported the clinical plausibility (efficacy) of AA towards
realizing its translational advantage. Here, we provide an overview of AA with regard to its potential in the management
of cancer disease.
