Title:Amyotrophic Lateral Sclerosis Treatment with Ultramicronized Palmitoylethanolamide: A Case Report
Volume: 11
Issue: 7
Author(s): Simonetta Clemente
Affiliation:
Keywords:
Mast cells, microglia, motor neuron disease, neurodegeneration, electromyography, spinal inflammation, palmitoylethanolamide, dampen mast cell, microglia activation, pulmonary function
Abstract: Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by progressive degeneration of
motor neurons which leads to muscular atrophy, paralysis and death in 3-5 years from starting symptoms. This disorder is
accompanied by noteworthy spinal inflammation mediated in particular by microglia and mast cells. No effective therapy
is available. This report describes the effects of administering the anti-inflammatory agent palmitoylethanolamide in a
case of sporadic amyotrophic lateral sclerosis. Palmitoylethanolamide treatment led to an improved clinical picture, as
evidenced by electromyographic analysis and pulmonary function. Conceivably, the action of palmitoylethanolamide
could result, in part, from its ability to dampen mast cell and microglia activation.
