Title:Developing Phytoestrogens for Breast Cancer Prevention
Volume: 12
Issue: 10
Author(s): Mandy M. Liu, Ying Huang and Jeffrey Wang
Affiliation:
Keywords:
Phytoestrogens, Breast cancer, Chemoprevention, Estrogen receptor modulator, Aromatase inhibitor, Genistein, Daidzein, Glycitein, Equol, Matairesinol, Secoisolariciresinol, Sesamin, Enterolactone, Enterodiol, Resveratrol, Coumestrol
Abstract: Breast cancer is one of the most common types of cancer in women, and is the second leading cause of cancer-related deaths in
the United States. Chemoprevention using phytoestrogens (PEs) for breast cancer may be a valid strategy. PEs are phytochemicals with
estrogen-like structures and can be classified into four types: isoflavones, lignans, stilbenes and coumestans. They are widely distributed
in diet and herbs and have shown anti-cancer activity via mechanisms including estrogen receptor modulation, aromatase inhibition, and
anti-angiogenesis. Genistein, daidzein and resveratrol are some of the most studied PE examples. Quality control in product
manufacturing and clinical study design is a critical issue in developing them as clinically effective chemopreventive agents for breast
cancer.
