Title:Plants vs. Cancer: A Review on Natural Phytochemicals in Preventing and Treating Cancers and Their Druggability
Volume: 12
Issue: 10
Author(s): Hu Wang, Tin Oo Khor, Limin Shu, Zheng-Yuan Su, Francisco Fuentes, Jong-Hun Lee and Ah-Ng Tony Kong
Affiliation:
Keywords:
Anti-cancer, Chemoprevention, Druggability, Mechanism, Natural compounds, Pathway, Phytochemical, breast cancer, colon cancer, human lung cancer
Abstract: Cancer remains to be one of the leading causes of death in the United States and around the world. The advent of modern
drug-targeted therapies has undeniably improved cancer patients' cares. However, advanced metastasized cancer remains untreatable.
Hence, continued searching for a safer and more effective chemoprevention and treatment is clearly needed for the improvement of the
efficiency and to lower the treatment cost for cancer care. Cancer chemoprevention with natural phytochemical compounds is an
emerging strategy to prevent, impede, delay, or cure cancer. This review summarizes the latest research in cancer chemoprevention and
treatment using the bioactive components from natural plants. Relevant molecular mechanisms involved in the pharmacological effects of
these phytochemicals are discussed. Pharmaceutical developmental challenges and opportunities in bringing the phytochemicals into the
market are also explored. The authors wish to expand this research area not only for their scientific soundness, but also for their potential
druggability.
