Title:Actual Knowledge of Systemic Inflammation Reaction During Cardiopulmonary Bypass
Volume: 7
Issue: 3
Author(s): Asmae Belhaj
Affiliation:
Keywords:
Cardiopulmonary bypass, statins, methylprednisolone, TNFalpha
Abstract: Systemic inflammation response is a complex physiopathological host response following aggression. This
phenomenon is well described during cardiac surgery under cardiopulmonary bypass but also in the context of off-pump
cardiac surhery. The goal of this article is to review the different mechanisms involved in the systemic inflammation
response, abusively called “systemic inflammatory response syndrome”. The article will describe the different component
of this response with a clear definition of different pathways found in this process. The possible relation between systemic
inflammation and postoperative outcome will be described. The different therapeutic and prophylactic options evaluated
to decrease the systemic inflammation reaction will be summarized.
