Title:Analysis Toward Innovative Herbal Antibacterial & Antifungal Drugs
Volume: 7
Issue: 3
Author(s): Sandeep Dhankhar, Seema Dhankhar, Manish Kumar, Sonam Ruhil, Meenakshi Balhara and Anil K. Chhillar
Affiliation:
Keywords:
Antimicrobial, Aspergillus species, Catharanthus roseus, drugs, medicinal plants, patents, medicinal plants, Reference Strain, Bacterial Culture, Dilution Assay, Gas Chromatography Mass Spectrometric
Abstract: The antimicrobial activities of four medicinal plants Argemona mexicana, Achyranthes aspera, Catharanthus
roseus, and Syzygium cumini were evaluated against Escherichia coli, Vibrio cholerae, Klebsiella pneumoniae, Proteus
vulgaris, Bacillus subtilis, Salmonella typhi and three Aspergillus species. Extracts from Achyranthes aspera and Catharanthus
roseus showed the highest antimicrobial potential (MIC 0.375-0.750 mg/ml) while extract from Argemona
mexicana and Syzygium cumini, showed less activity. In disc diffusion assay, only eight out of twenty extracts showed antimicrobial
activity at a concentration of 25.0 μg/ disc. The GCMS investigation reveals the existence of 2-bornanone; 1,
2-benzenedicarboxylic acid, bis (2-methylpropyl) ester; hexadecanoic acid, methyl ester and hexatriacontane in water extract
fraction of C. roseus. The present research article provides a review of some medicinal plants incorporating antimicrobial
drugs, together with recent advances in emerging therapeutics in clinical development and related patents for exploitation
of herbal medicine.
