Title:Targeting Molecular Imaging of Breast Cancer by Radioimmunodetection Method in Nuclear Medicine
Volume: 1
Issue: 1
Author(s): Zahra Heidari and Mojtaba Salouti
Affiliation:
Keywords:
Breast cancer, nuclear medicine, targeting molecular imaging, radioimmunodetection.
Abstract: Early diagnosis remains the best method of improving the odds of curing breast cancer. Mammography is an
effective imaging tool in diagnosis of breast cancer. However, false negatives occur frequently, particularly when imaging
post-surgical recurrence, fibrocystic breast disease and dense breast tissue in younger women. Other imaging modalities
such as ultrasonography, magnetic resonance imaging and computed tomography initiated to increase the diagnostic accuracy
of mammography, have strengths and weaknesses in terms of sensitivity, specificity, spatial and temporal resolution,
contrast and cost. The application of nuclear medicine techniques to study patients with breast cancer has recently raised
its profile, particularly in the investigation of indeterminate mammographic lesions and for overcoming limitations of
other imaging techniques. For increasing sensitivity and specificity of nuclear medicine techniques, researchers are studying
on targeted molecular imaging methods. The recent advances in molecular and cellular biology have facilitated the
discovery of novel molecular targets of breast tumor cells such as key molecules involved in proliferation, differentiation,
cell death and apoptosis, angiogenesis and metastasis. In this paper, the history of radioimmunodetection of breast cancer
as a targeting molcular imaging method will be reviewed.
