Title:Resolving Biofilm Infections: Current Therapy and Drug Discovery Strategies
Volume: 13
Issue: 11
Author(s): Max V. Ranall, Mark S. Butler, Mark A. Blaskovich and Matthew A. Cooper
Affiliation:
Keywords:
Antibiotic, antibiotic resistance, bacteria, biofilm, drug discovery, infection, screening, pathogenic bacteria, assays.
Abstract: Biofilms formed by pathogenic bacteria present a serious threat to human health as the efficacy of standard antibiotic
therapeutic regimens is compromised by reduced microbial susceptibility within the biofilm environment. The discovery
of improved therapies for biofilm elimination requires an understanding of biofilm formation and dispersal, and
the development of assays to specifically analyze these dynamic processes. This review will discuss biofilm screening
strategies suitable for drug discovery efforts, especially chemical and biological approaches that specifically target biofilm
destruction.
