Title:Regulation of Cell Death and Survival by Resveratrol: Implications for Cancer Therapy
Volume: 12
Issue: 8
Author(s): Simone Fulda
Affiliation:
Keywords:
Apoptosis, Cancer, Cancer therapy, Resveratrol, Signaling, cell death, preventapoptosis, antitumor, apoptotic cell death, membranestimulates, oligomerization, mitochondrial
Abstract: Apoptosis is a critical regulatory mechanism to control tissue homeostasis. Accordingly, too little apoptosis can contribute to
cancer. Natural compounds, e.g. polyphenols such as resveratrol, have emerged as promising agents for cancer chemoprevention and
therapy, since they interfere with various major signaling cascades that are aberrantly regulated in cancers. For example, resveratrol can
antagonize signaling events that prevent apoptosis or support cancer proliferation. Further elucidation of the signaling events that are
regulated by resveratrol is anticipated to path the way for the transfer of resveratrol and its derivatives into clinical application for
chemoprevention or treatment of human cancers.
