Title:Animal Models in Neurology: Drawbacks and Opportunities
Volume: 18
Issue: 29
Author(s): Robert Patejdl and Uwe K. Zettl
Affiliation:
Keywords:
Animal models, neurology, multiple sclerosis, encephalitogenic epitopes, experimental autoimmune encephalomyelitis, microarray, transgene animals, natalizumab, Parkinson’s disease, conditioned reflex.
Abstract: Animal models have been used widely in neurology since many decades. They have led to an improved understanding of the
pathophysiological processes underlying frequent diseases as multiple sclerosis or Parkinson’s disease and enabled the development of
highly effective therapeutical approaches. Current developments, drawbacks and limitations of animal models in neurology are discussed
with a special focus on the experimental autoimmune encephalomyelitis – model of multiple sclerosis.
