Title:Acute Coronary Syndromes as Auto-Inflammatory Disorders
Volume: 18
Issue: 28
Author(s): Makoto Suzuki
Affiliation:
Keywords:
acute coronary syndromes, inflammation, leukocyte, vascular endothelial cell, vascular smooth muscle cell, platelet, cholesterol, reactive oxygen species, cross-talk mechanisms, C-reactive protein
Abstract: From the onset to the healing stage of acute coronary syndromes, an endless inflammation has been presented with complex,
multiple cross-talk mechanisms at the molecular, cellular, and organ levels. Even though the early reperfusion treatment either by thrombolysis
or percutaneous coronary intervention provides the excellent clinical benefits in patients with acute coronary syndromes, ischemia/
reperfusion injury may somewhat offset those great advantages. Inflammation, although potentially protective, has been deeply associated
with those detrimental conditions. The hexagonal vascular inflammatory network which is composed of activated various leukocytes,
vascular endothelial cells, vascular smooth muscle cells, platelets, excess reactive oxygen species, and cholesterol may contribute
these vicious circles. To address these complex syndromes with more benefits regarding the prevention and treatment, this review comprehensively
updates the pathogenesis of acute coronary syndromes from the view points of vascular inflammation.
