Title:Inflammation in Peripheral Arterial Disease (PAD)
Volume: 18
Issue: 28
Author(s): Salvatore Santo Signorelli, Massimiliano Anzaldi and Valerio Fiore
Affiliation:
Keywords:
Peripheral arterial disease, phlogosis, biomarkers, medical therapy, inflammation, inflammatory biomarkers, atherosclerotic diseases, T-lymphocytes, C-reactive protein (CRP), Metalloproteinase (MMPS)
Abstract: Peripheral arterial disease (PAD) affects a large number of individuals over the age of 55 years old, and data from studies has
shown a relationship between inflammation, and PAD. Many researchers have not only focused on the role played by inflammatory biomarkers
and the progression of PAD, but also on the efficiency of biomarkers in monitoring medical, surgical and interventional strategies
in PAD patients. In this review, Authors aim to demonstrate that biomarkers play a key role in the pathophysiology of PAD, and
consequently they could be screened to highlight individuals showing these crucial pathophysiological signs. Based on a large debate
about phlogosis, it is now considered to be a relevant objective in reducing the prevalence and consequences of atherosclerotic diseases
such as PAD. Finally, efforts must be made towards addressing this very important objective, and consequently a greater number of studies
need to be made in combatting phlogosis, especially among PAD patients.
