Title:Current Genomics in Cardiovascular Medicine
Volume: 13
Issue: 6
Author(s): Vinit Sawhney, Scott Brouilette, Dominic Abrams, Richard Schilling and Benjamin O'Brien
Affiliation:
Keywords:
Cardiovascular disease, GWAS, Gene sequencing, Personalised medicine, Pharmacogenetics, lysosomal lipase acid A gene, morbidity, mortality, pregenome, alleles
Abstract: Cardiovascular disease (CVD) is a heterogeneous, complex trait that has a major impact on human morbidity
and mortality. Common genetic variation may predispose to common forms of CVD in the community, and rare genetic
conditions provide unique pathogenetic insights into these diseases. With the advent of the Human Genome Project and
the genomic era, new tools and methodologies have revolutionised the field of genetic research in cardiovascular medicine.
In this review, we describe the rationale for the current emphasis on large-scale genomic studies, elaborate on genome
wide association studies and summarise the impact of genomics on clinical cardiovascular medicine and how this
may eventually lead to new therapeutics and personalised medicine.
