Title:Tumor Invasion and Oxidative Stress: Biomarkers and Therapeutic Strategies
Volume: 12
Issue: 6
Author(s): L. Muinelo-Romay, L. Alonso-Alconada, M. Alonso-Nocelo, J. Barbazan and M. Abal
Affiliation:
Keywords:
Anti-cancer therapy, biomarker, carcinoma invasion, hypoxia, inflammation, metastasis, oxidative
stress, ROS, tumor dissemination, oncology, malignancy, tumor phenotype, microenvironment, genetic mutations, tissue homeostasis
Abstract: Tumor invasion is paradigmatic of the complex interactions connecting a carcinoma with its
environment, and a reflex of the cellular and molecular heterogeneity that defines the initiation of dissemination
and metastasis. The hostile situation generated by a growing carcinoma and a reactive stroma is at the basis
of the promotion of carcinoma invasion and metastasis, with oxidative stress emerging as a main player in the
acquisition of an aggressive tumor phenotype. In this review, we present this complex scenario with a focus on
the contribution of the reactive environment and the oxidative stress to the cellular and molecular events
associated with carcinoma invasion and metastasis. We also discuss the potential of oxidative stress as a
source of biomarkers of advance disease, and as supplier of a therapeutic armamentarium against the initial
steps of metastatic dissemination.
