Title:Small Diverse Antioxidant Functionalities for Oxidative Stress Disease Drug Discovery
Volume: 12
Issue: 8
Author(s): D. Sikazwe, A. Grillo, S. Ramsinghani, J. Davis, K. McQuiston and S. Y. Ablordeppey
Affiliation:
Keywords:
Catalase, cytoprotective, neuroprotective, oxidative stress, phenolic, radicals, scavengers, superoxide dismutase.
Abstract: There is an up-surge of interest in antioxidants because of their potential use in mitigating a wide array of
oxidative stress mediated diseases. In the course of our literature search for diverse functional groups, with utility in the
design of potential drugs for preventing oxidative stress related cell injury, we have collected a small literature library of
core structures or moieties possessing antioxidant activities. These functional groups can be re-configured into robust
antioxidants drug molecules, in their own right, or incorporated into drug structures where the antioxidant capability is
required. The lack of single papers presenting a collection of diverse small molecule antioxidant moieties as potential
design leads prompted us to write this short review of twenty five such functionalities.
