Title:BCL-2 Family Proteins: The Mitochondrial Apoptotic Key Regulators
Volume: 8
Issue: 2
Author(s): P. Daisy and K. Saipriya
Affiliation:
Keywords:
Apoptosis, Bcl-2 family, BH-3 Domain, Molecular pathways, Small molecule inhibitors
Abstract: Apoptosis is an induced and ordered process in which the cell actively participates in bringing about its own
death. Dysregulation in either of the apoptotic pathways leads to various diseases including cancer, neurodegenerative
disorders and autoimmunity. Bcl-2 (B cell lymphoma 2) proteins such as pro-and anti-apoptotic play a vital role in the mitochondrial
pathway of apoptosis which results in cellular commitment to death or cell survival. So, therefore many small
molecule antagonists that targets Bcl-2 anti-apoptotic proteins that lead to cellular survival are in their pre-clinical and
clinical stages. In this review we focus on the apoptotic players of Bcl-2 group of proteins and their anti-apoptotic inhibitors.
