Title:Cocaine and Acute Vascular Diseases
Volume: 5
Issue: 2
Author(s): A. De Giorgi, F. Fabbian, M. Pala, F. Bonetti, I. Babini, I. Bagnaresi, F. Manfredini, F. Portaluppi, D. P. Mikhailidis and R. Manfredini
Affiliation:
Keywords:
Cocaine, cardiovascular disease, chest pain, vasoconstriction, myocardial infarction, congestive heart failure,
arrhythmias, stroke, kidney ischemia, kidney failure
Abstract: Cocaine is one of the most widely used drugs of abuse. Chest pain is the most common side effect requiring
emergency visits after cocaine use. Vasoconstriction and platelet activation are the main effects of cocaine in the
vasculature. In this brief review, we consider the most important clinical effects of cocaine abuse on the heart, brain and
kidney. Symptoms related to cocaine toxicity such as myocardial infarction, congestive heart failure, arrhythmias, aortic
dissection, stroke, renal failure, are similar to the clinical picture of atherosclerotic vascular damage, even if the age of
cocaine abusers is usually in the second and third decades. Clinicians (especially emergency department physicians)
should consider substance abuse among the differential diagnosis of chest pain in young people.
