Title:Targeting Chemokines in Cancer
Volume: 8
Issue: 2
Author(s): Raffaella Bonecchi, Benedetta Savino, Alberto Mantovani and Massimo Locati
Affiliation:
Keywords:
Cancer, chemokine, chemokine receptor, inflammation
Abstract: The chemokine system is now recognized as a key element in cancer-related inflammation because it can affect
tumor progression acting on tumor-stroma and also directly on tumor cells. Chemokines are produced by both tumor cells
and the tumor microenvironment and modulate not only leukocyte infiltration and angiogenesis but also senescence, cell
survival and metastasis. Here, we review available information in preclinical and clinical settings that suggest that the
chemokine system represents a valuable target for the development of innovative therapeutic strategies.
