Title: Application of In-Line Liquid Chromatography-Accurate Radioisotope Counting-Mass Spectrometry (LC-ARC-MS) to Evaluate Metabolic Profile of [3H]-Mefenamic Acid in Rat Plasma
Volume: 1
Issue: 3
Author(s): Wing Lam, Cho-Ming Loi, James Atherton, Wayne Stolle, John Easter and Abdul Mutlib
Affiliation:
Keywords:
Mefenamic acid metabolism, sulfate, glucuronide, LC-ARC-MS, plasma
Abstract: Profiling of rat plasma using a highly sensitive LC-ARC-MS technique showed that [3H] mefenamic acid was metabolized to several products, including a sulfate conjugate and a hydroxylated analogue as major metabolites. This technique of detecting low levels of radioactivity in plasma was superior to previously used methods, such as β-RAM detectors.
