Title: Extended-Spectrum Cephalosporinases in Enterobacteriaceae
Volume: 6
Issue: 1
Author(s): Hedi Mammeri and Patrice Nordmann
Affiliation:
Keywords:
ESAC, extended-spectrum cephalosporinase, cefepime, ceftazidime
Abstract: Extended-spectrum AmpC β-lactamases are derived from chromosomal cephalosporinases by amino acid deletion, insertion and replacement. These structural changes are responsible for an increased catalytic efficiency against extended- spectrum cephalosporins, such as ceftazidime, cefotaxime, cefepime, and cefpirome. An overview of the molecular and biochemical characterization of these identified β-lactamases in Enterobacteriaceae is provided. The structural modifications that account for the broadening substrate specificity and the phenotypes of resistance of the clinical isolates are detailed.
