Title: Leptin in Non-Autoimmune Inflammation
Volume: 8
Issue: 4
Author(s): Chunlin Cai, Bevra H. Hahn, Giuseppe Matarese and Antonio La Cava
Affiliation:
Keywords:
Leptin, inflammation, metabolism
Abstract: Leptin is an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine and pro-inflammatory immune responses. Several studies have implicated leptin in the pathogenesis of chronic autoimmune inflammatory conditions such as autoimmune encephalomyelitis, intestinal bowel inflammation and type-1 diabetes. This review focuses on the role of leptin in non-autoimmune inflammatory diseases that include renal, liver and lung inflammation, atherosclerosis and metabolic syndrome, Behcets disease and endometriosis.
