Title: Recent Developments in the Discovery of Selective Glucocorticoid Receptor Modulators (SGRMs)
Volume: 8
Issue: 9
Author(s): Andrew R. Hudson, Steven L. Roach and Robert I. Higuchi
Affiliation:
Keywords:
SGRM, glucocorticoid, nonsteroidal, modulator, transactivation, transrepression, dissociated, inflammation, multiple myeloma
Abstract: Steroidal glucocorticoids are widely prescribed for the treatment of a variety of inflammatory and autoimmune diseases. Although they are effective, the side-effects associated with chronic glucocorticoid treatment, such as osteoporosis and hyperglycemia, can severely limit their long-term use. Hence, there is a need to develop new effective anti-inflammatory agents for systemic use which are dissociated from their unwanted side effects.
