Title: Novel “Three-in-one” Peptide Device for Genetic Drug Delivery
Volume: 10
Issue: 1
Author(s): Jason Smith, Jesse Guidry and Pernilla Wittung-Stafshede
Affiliation:
Keywords:
antisense, oligonucleotides, drug-delivery, circular dichroism, fluorescence, liposomes, carboxyfluorescein, peptide device, genetic drug delivery
Abstract: We here describe a new strategy for the delivery of oligonucleotides to cells that is based on the use of a short peptide containing three functional units: a membrane-penetrating segment, a DNA-binding domain and a cell-localization sequence. The designed vector binds strongly to oligonucleotides and has membrane-perturbing abilities in vitro. This type of multi-functional device may be a powerful tool to achieve efficient delivery of genetic drugs in vivo.
