Title: The Impact of Combinatorial Methodologies on Medicinal Chemistry
Volume: 4
Issue: 7
Author(s): Rosario M. Sanchez-Martin, Stifun Mittoo and Mark Bradley
Affiliation:
Keywords:
Methodologies, scavengers, combinatorial chemistry
Abstract: Combinatorial chemistry has had a major impact on the discovery and optimisation of potential lead compounds. This review details some of the fundamental principles behind combinatorial chemistry and describes a variety of methods employed in the search for new therapeutically interesting compounds including the concept of dynamic combinatorial chemistry as a method of selecting active compounds from a mixture. It also outlines methods used to analyse resin bound products and describes how solution phase library generation may be aided by the use of resin bound reagents and scavengers.
