Title: Recombinant Murine Polyoma Virus-like-particles Induce Protective Antitumour Immunity
Volume: 1
Issue: 2
Author(s): M. Brinkman, J. Walter, I. Jennes, M. Neugebauer, W. Bertling, S. Grein, M. Thies, M. Weigand, T. Beyer and M. Herrmann
Affiliation:
Keywords:
peptide delivery, cell-mediated immunity, virus-like-particles, tumour vaccination
Abstract: Subcutaneous vaccination of mice with chimerical polyomavirus-likeparticles consisting of a VP1-ovalbumin (OVA252-270) fusion protein induced immunodominant H-2Kb-restricted and OVA257-264-specific CD8 T cells in mice. Single immunisations with VP1-OVA252-270 capsoids failed to have beneficial effects on tumour protection, only double vaccinations in weekly intervals protected mice from lethal MO5 melanoma challenge.
