α-Synuclein and the Pathogenesis of Parkinsons Disease

Title: α-Synuclein and the Pathogenesis of Parkinsons Disease

Volume: 11 Issue: 3

Author(s): Francis L. Martin, Sally J.M. Williamson, Katerina E. Paleologou, David Allsop and Omar M.A. El-Agnaf

Affiliation:

Keywords: dna single-strand breaks, comet assay, reactive oxygen species, environmental causation

Abstract: Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinsons disease (PD) patients. Intracellular aggregation of α-synuclein (α-syn) appears to play a key role in the generation of LBs and LNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.

Cite this article as:

Martin L. Francis, Williamson J.M. Sally, Paleologou E. Katerina, Allsop David and El-Agnaf M.A. Omar, α-Synuclein and the Pathogenesis of Parkinsons Disease, Protein & Peptide Letters 2004; 11 (3) . https://dx.doi.org/10.2174/0929866043407138