Design and Synthesis of Phosphonodifluoromethyl Phenylalanine (F2Pmp):A Useful Phosphotyrosyl Mimetic

Terrence   R.   Burke

doi:10.2174/156802606777951091

Abstract

Hydrolytically-stable phosphotyrosyl (pTyr) mimetics can be useful tools for the study of cellular signal transduction processes. Among pTyr mimetics reported to date, phosphono(diflouromethyl)phenylalanine (F2Pmp) has shown particular utility when dealing with protein-tyrosine phosphatases (PTPs). The current overview presents the development of F2Pmp and a summary of approaches toward its synthesis and use.

Keywords: phosphonic acids, fluorination, dimethylacetamide, DAST, ketophosphonate

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Current Topics in Medicinal Chemistry

Title: Design and Synthesis of Phosphonodifluoromethyl Phenylalanine (F2Pmp):A Useful Phosphotyrosyl Mimetic

Volume: 6 Issue: 14

Author(s): Terrence R. Burke

Affiliation:

Keywords: phosphonic acids, fluorination, dimethylacetamide, DAST, ketophosphonate

Abstract: Hydrolytically-stable phosphotyrosyl (pTyr) mimetics can be useful tools for the study of cellular signal transduction processes. Among pTyr mimetics reported to date, phosphono(diflouromethyl)phenylalanine (F2Pmp) has shown particular utility when dealing with protein-tyrosine phosphatases (PTPs). The current overview presents the development of F2Pmp and a summary of approaches toward its synthesis and use.

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Cite this article as:

Burke R. Terrence, Design and Synthesis of Phosphonodifluoromethyl Phenylalanine (F2Pmp):A Useful Phosphotyrosyl Mimetic, Current Topics in Medicinal Chemistry 2006; 6 (14) . https://dx.doi.org/10.2174/156802606777951091

DOI https://dx.doi.org/10.2174/156802606777951091	Print ISSN 1568-0266
Publisher Name Bentham Science Publisher	Online ISSN 1873-4294

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