Title: PCL/PEG Copolymeric Nanoparticles: Potential Nanoplatforms for Anticancer Agent Delivery
Volume: 12
Issue: 8
Author(s): MaLing Gou, XiaWei Wei, Ke Men, BiLan Wang, Feng Luo, Xia Zhao, YuQuan Wei and ZhiYong Qian
Affiliation:
Keywords:
Biodegradable polymer, cancer, diagnostic agent, drug delivery system, gene delivery, nanoparticle, poly(-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymers, vaccine, nano-precipitation method, chemotherapy
Abstract: Nanotechnology provides researchers with new tools for cancer treatment. Biodegradable polymeric nanoparticles, as an advanced drug delivery system, have promising applications in cancer treatment. Poly(- caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymers are biodegradable and amphiphilic, and show potential application in drug delivery. In recent years, PCL/PEG copolymeric nanoparticles, as a potential nanoplatform for anticancer agent delivery, received increasing attention. This paper reviews PCL/PEG copolymer nanoparticles for anticancer agent delivery, including overcoming water insolubility of hydrophobic drug, targeting chemotherapeutic drug to tumor, and delivering genes, vaccines, and diagnostic agents.
