Non-Peptidic α-Helical Mimetics as Protein-Protein Interaction Inhibitors

Title: Non-Peptidic α-Helical Mimetics as Protein-Protein Interaction Inhibitors

Volume: 18 Issue: 16

Author(s): M. B. Dewal and S. M. Firestine

Affiliation:

Keywords: α-helical mimetics, protein-protein interactions, benzoylurea, enaminone, non-peptidic, oxopiperazine, terephenyls, terephthalamides, heterocycles, benzamide, pyridazine, amphiphilic, hydrogen bond, hydrophilic

Abstract: Protein-protein interactions play a major role in almost all biological pathways and thus, these interactions have a profound impact on the pathogenesis of diseases. The ability to modulate protein-protein interactions with small molecules is an important and rapidly growing area in the field of medicinal chemistry. One of the most common secondary protein structures that are involved in protein-protein interactions are α-helices. Thus, a common approach towards developing inhibitors of protein-protein interactions is to design non-peptidic small molecules that mimic the spatial orientations of the side chains of an α-helix. In this review, we will discuss a variety of small molecules including terephenyls, terephthalamides, benzamides, enaminones, benzoylureas, pyridines, imidazoles, thiazoles, pyridazines, piperazines, oxopiperazines and diphenylindanes that have been published from 2005-2010 as small molecule α- helical mimetics.

Cite this article as:

B. Dewal M. and M. Firestine S., Non-Peptidic α-Helical Mimetics as Protein-Protein Interaction Inhibitors, Current Medicinal Chemistry 2011; 18 (16) . https://dx.doi.org/10.2174/092986711795843227