Title: Chemistry and Biological Activities of Buxus Alkaloids
Volume: 7
Issue: 1
Author(s): Yu-Xin Yan, Yun Sun, Zhong-Rong Li, Lin Zhou and Ming-Hua Qiu
Affiliation:
Keywords:
Buxaceae, Buxus alkaloid, cyclovirobuxine D, structure modification, biological activity, triterpenoid alkaloids, plant sources, antibacterial, herbal medicine, anti-myocardial ischemia
Abstract: Triterpenoid alkaloids are one of the most important classes that have been studied. Buxus alkaloids are such a type of triterpenoid alkaloids of cycloartenol skeleton with a degraded C-20 side chain, and with the nitrogen containing substituents at C-3 and/or C-20. 219 Buxus alkaloids have been reported so far. This review article focuses on the structural characters, plant sources and biological activities of Buxus alkaloids. This review includes anti-myocardial ischemia, inhibition of acetyl- and butyryl-cholinesterases, cytotoxicity and antibacterial activities. The biological activities, mechanisms and structure modifications of cyclovirobuxine D (CVB-D) are also described.
