Title:Mn-SOD and Chronic Inflammation of Gastric Mucosa
Volume: 9
Issue: 4
Author(s): J. Dovhanj, D. Svagelj, M. Smolic, R. Smolic and I. Maric
Affiliation:
Keywords:
Free radical, gastric mucosa, inflammation, oxidative stress, ROS, SOD.
Abstract: The involvement of reactive oxygen species in the inflammatory tissue destruction is well known. Significant
changes in the activity and expression of several isoforms of superoxide dismutase were observed in the human gastric
disease. Mn-SOD attracted the attention of researchers because of its inducibility by oxidative stress. There is increasing
evidence that oxidative stress plays a role in the progression of mucosal damage leading to gastric cancer. The evaluation
of possible modulation of Mn-SOD activity during chronic inflammation of gastric mucosa could reveal whether its assessment
is important to prevent the accumulation of gastric epithelial cell damage and thereby reduce the risk of gastric
carcinoma.
