Title: Immunotherapy of Human Cancers Using Gene Modified T Lymphocytes
Volume: 9
Issue: 5
Author(s): Juan F. Vera, Malcolm K. Brenner and Gianpietro Dotti
Affiliation:
Abstract: Adoptive T cell therapies can produce objective clinical responses in patients with hematologic and solid malignancies. Genetic manipulation of T lymphocytes has been proposed as a means of increasing the potency and range of this anti-tumor activity. We now review how coupling expression of transgenic receptors with countermeasures against potent tumor immune evasion strategies is proving highly effective in pre-clinical models and describe how these approaches are being evaluated in human subjects.
