Title: Molecular Determinants of Fluoroquinolone Antibacterial Agents Pharmacokinetics
Volume: 4
Issue: 3
Author(s): Dominique Leveque and Francois Jehl
Affiliation:
Keywords:
Fluoroquinolone, ciprofloxacin, ofloxacin, levofloxacin, moxifloxacin, pharmacokinetics, enzymes, drug transporters
Abstract: This review presents the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of fluoroquinolones pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug-drug interactions) is also discussed.
