Title: Recent Developments in the Chemistry of Thebaine and its Transformation Products as Pharmacological Targets
Volume: 16
Issue: 25
Author(s): Sandor Berenyi, Csaba Csutoras and Attila Sipos
Affiliation:
Keywords:
Thebaine, morphinandiene, opioid activity, dopamine activity, orvinols
Abstract: The most practical synthetic routes to the preparation of as important pharmaceuticals as oxycodone, naloxone, naltrexone, nalbuphine and buprenorphine have utilized the alkaloid, thebaine, as a starting material. This review intends to focus on chemical transformations of morphinans which resulted in morphinandiene derivatives with well-established and novel pharmacological potencies. These chemical transformations were mainly associated with the formation and substitution of the unique diene structure of the ring C of the morphinan backbone.
