Title:Recent Advances in Functions and Biotechnological Potential of Pleiotropic Transcriptional Factor AdpA
Volume: 13
Issue: 3
Author(s): Bohdan Ostash*
Affiliation:
- Department of Genetics and Biotechnology, Faculty of Biology, Ivan Franko National University of Lviv, Lviv,
Ukraine
Keywords:
Streptomyces, natural products, antibiotics, pleiotropic regulation, transcriptional factors, adpA.
Abstract: The specialized metabolism of the members of class Actinomycetes served as one of
the deepest sources of compounds for the pharmaceutical industry. Within this class species of
genus Streptomyces stand out as the most diverse and prolific producers of novel scaffolds. At
some point at the end of the 20th century, chemical-microbiological screening of actinomycetes
seemed to largely sample their specialized metabolism chemical space. Contrary to traditional discovery
methods that directly focus on the molecule or its bioactivity, the availability of sequenced
actinomycete genomes opens the door for novel biosynthetic gene clusters (BGC) for specialized
metabolism. The genome-based approaches reveal the striking richness and diversity of BGCs, to
which the “pre-genome” discovery paradigm was myopic. In most cases, small molecules encoded
within these BGCs remain unknown, and finding efficient ways to probe such unexplored
BGCs becomes one of the pressing issues of current biotechnology. Here, the focus is on the biology
of pleiotropic transcriptional factor (TF) AdpA, whose gene is invariably present in Streptomyces
genomes. The review will portray how this TF impacts the morphogenesis and metabolism
of Streptomyces and how it can be exploited to discover novel natural products.
