Title:Efficient Green Synthesis and Characterization of Benzil and its Derivatives Using Microwave Irradiation
Volume: 22
Issue: 3
Author(s): Krina Patel, Drashti Shah, Dev Jani, Neel Savaliya, Dharti Patel, Ashish Shah, Pinkal Patel and Ashish Patel*
Affiliation:
- Department of Pharmaceutical Chemistry, Ramanbhai Patel College of Pharmacy, Charotar University of Science and
Technology, CHARUSAT Campus, Changa-388421, Gujarat, India
Keywords:
Benzil, microwave-assisted synthesis, green chemistry, one-pot synthesis, green oxidant, catalyst-free, Kornblum- Oxidation, Iodine.
Abstract: The main aim of the present work was to conduct the one-pot microwave-assisted green
synthesis of benzil and its derivatives. Benzil is acknowledged as a pivotal scaffold in the realm of
medicinal and organic chemistry, owing to its extensive utilities. Due to the various merits of the
green technology approach compared to classical methodology and the provision of sustainable
chemistry, this reaction has received renewed interest for preparing benzil derivatives in an environmentally
friendly manner with improved yields. We have, herein, presented a highly efficient route
for the synthesis of benzil derivatives utilizing acetophenone and benzene derivatives as primary
substrates. Notably, this synthesis obviates the necessity for any potentially hazardous catalyst and
employs microwave irradiation and iodine green oxidant to facilitate the reaction. All synthesized compounds
were characterized by spectroscopic techniques, such as IR, 1H NMR, and mass spectrometry. A
green and efficient microwave-assisted synthesis methodology for benzil and its derivatives has been
developed using iodine green oxidant. This approach has yielded the desired benzil derivatives with
remarkable efficiency, achieving yields ranging from 91% to 97% within a short time of 10-15 minutes;
the derivatives have been characterized using spectral techniques, viz., IR, 1H NMR, and mass spectrometry.
It is noteworthy that the entire reaction optimization process has been conducted in an environmentally
friendly manner, thereby exemplifying a synthetic methodology being both environmentally
sustainable and economically viable, compared to conventional techniques.
