Unveiling the Molecular Mechanism of Diosmetin and its Impact on
Multifaceted Cellular Signaling Pathways

Krishna Kumar      Varshney; Jeetendra Kumar      Gupta; Rajnish      Srivastava
doi:10.2174/0109298665294109240323033601
Abstract

Background: Diosmetin is an O-methylated flavone and the aglycone part of the flavonoid glycosides diosmin that occurs naturally in citrus fruits. Pharmacologically, diosmetin is reported to exhibit anticancer, antimicrobial, antioxidant, oestrogenic, and anti-inflammatory activities.
Objective: This comprehensive review was aimed to critically explore diverse pharmacological activities exhibited by diosmetin. Along with that, this review can also identify potential research areas with an elucidation of the multifactorial underlying signaling mechanism of action of diosmetin in different diseases.
Methods: A comprehensive collection of evidence and insights was obtained from scientific journals and books from physical libraries and electronic platforms like Google Scholar and PubMed. The time frame selected was from year 1992 to July 2023.
Results: The review delves into diosmetin's impact on cellular signaling pathways and its potential in various diseases. Due to its ability to modulate signaling pathways and reduce oxidative stress, it can be suggested as a potential versatile therapeutic agent for mitigating oxidative stressassociated pathogenesis.
Conclusion: The amalgamation of the review underscores diosmetin's promising role as a multifaceted therapeutic agent, highlighting its potential for drug development and clinical applications.
Keywords: Antioxidant, clinical, diosmetin, drug development, flavonoid, multifaceted, signaling.
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Graphical Abstract

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DOI https://dx.doi.org/10.2174/0109298665294109240323033601	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305
Protein & Peptide Letters

Unveiling the Molecular Mechanism of Diosmetin and its Impact on Multifaceted Cellular Signaling Pathways

Abstract

Graphical Abstract

Therapeutic Proteins and Peptides of Plant Origin

Protein & Peptide Letters

Unveiling the Molecular Mechanism of Diosmetin and its Impact on Multifaceted Cellular Signaling Pathways

Abstract

Graphical Abstract

Call for Papers in Thematic Issues

Therapeutic Proteins and Peptides of Plant Origin

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