Title:Food-derived Peptides as Promising Neuroprotective Agents: Mechanism
and Therapeutic Potential
Volume: 24
Issue: 14
Author(s): Kavita Patel and Ashutosh Mani*
Affiliation:
- Department of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, Prayagraj, 211004, India
Keywords:
Neurodegenerative diseases, Food-derived peptides, Neuroprotection, Oxidative stress, Inflammation, Apoptosis.
Abstract: Many food-derived peptides have the potential to improve brain health and slow down
neurodegeneration. Peptides are produced by the enzymatic hydrolysis of proteins from different
food sources. These peptides have been shown to be involved in antioxidant and anti-inflammatory
activity, neuro-transmission modulation, and gene expression regulation. Although few peptides
directly affect chromatin remodeling and histone alterations, others indirectly affect the neuroprotection
process by interfering with epigenetic changes. Fish-derived peptides have shown
neuroprotective properties that reduce oxidative stress and improve motor dysfunction in Parkinson's
disease models. Peptides from milk and eggs have been found to have anti-inflammatory
properties that reduce inflammation and improve cognitive function in Alzheimer's disease models.
These peptides are potential therapeutics for neurodegenerative diseases, but more study is required
to assess their efficacy and the underlying neuroprotective benefits. Consequently, this review
concentrated on each mechanism of action used by food-derived peptides that have neuroprotective
advantages and applications in treating neurodegenerative diseases. This article highlights
various pathways, such as inflammatory pathways, major oxidant pathways, apoptotic pathways,
neurotransmitter modulation, and gene regulation through which food-derived peptides interact at
the cellular level.