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Current Topics in Medicinal Chemistry

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Highlights on Fluorine-containing Drugs Approved by U.S. FDA in 2023

Author(s): Saghir Ali, Andrew A. Bolinger and Jia Zhou*

Volume 24, Issue 10, 2024

Published on: 05 March, 2024

Page: [843 - 849] Pages: 7

DOI: 10.2174/0115680266300245240223070242

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Abstract

Fluorine continues to show its potential applications in drug discovery and development, as reflected by twelve drugs being fluorinated out of the fifty-five approved by the FDA in 2023. This concise review highlights the discovery of each of these fluorine-containing drugs in the past year, including its brand name, date of approval, composition, sponsors, indication, and mechanism of action. The relevant future trend is also briefly discussed.

Keywords: Fluorine, FDA approval, Fluorinated drugs, Small-molecule drug discovery, Diagnostic tools, Therapeutics.

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Graphical Abstract

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