Title:Advances in the Synthesis and Bioactivity of Polysaccharide Selenium
Nanoparticles: A Review
Volume: 24
Issue: 16
Author(s): Shiying Ye, Shaowei Sun, Jiye Cai and Jinhuan Jiang*
Affiliation:
- Institute of Pharmacy and Pharmacology, School of Pharmaceutical Science, Hengyang Medical School, University of
South China. Hengyang, Hunan, China
- Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive
Drug Research, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang,
Hunan, China
Keywords:
Selenium nanoparticles, polysaccharides, synthesis methods, anti-tumor, anti-inflammatory, antibacterial.
Abstract: Selenium, an essential trace element of the human body, is pivotal in human health and
disease prevention. Nevertheless, the narrow therapeutic index of selenium, where the toxic and
therapeutic doses are close, limits its clinical utility. Significantly, nanoscale selenium synthesized
by different methods using polysaccharides as stabilizers has low toxicity properties and exhibits
excellent bioactivity. Its biological activities, such as anti-tumor, anti-inflammatory, antioxidant,
antibacterial, and immune function enhancement, are improved compared with traditional organic
and inorganic selenium compounds, conferring greater potential for application in biomedicine.
Therefore, this review evaluates the advancements in various synthesis methodologies for polysaccharide
selenium nanoparticles (Se NPs) and their biological activities. It aims to provide a comprehensive
theoretical basis and research directions for the future development of highly efficient, minimally
toxic, and biocompatible polysaccharide-Se NPs and the application of polysaccharide-Se
NPs in biomedicine.